Type I Hypersensitivity Reaction

Overview

4.6 out of 5 (19 Reviews)

Credits

1.50

Post-Assessment Questions

11

Start Date

1 Sep 2023

Last Review Date

3 Aug 2025

Expiration Date

31 Aug 2026

Estimated Time To Finish

90 Minutes


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Activity Description

Type I or immediate hypersensitivity is an exaggerated immunoglobulin E (IgE)-mediated immune response to allergens such as pollen, dust mites, foods, medications, or insect venom, affecting nearly one-third of the global population. The reaction occurs when antigen-specific IgE binds to mast cells and basophils, triggering the release of inflammatory mediators, including histamine, tryptase, and proteases. Reactions may be immediate, delayed, or the cause of chronic allergic inflammation, as observed in sensitized individuals with ongoing exposure, such as pet owners with animal allergies. Clinical manifestations range from mild symptoms, including allergic rhinitis, urticaria, and atopic dermatitis, to severe, potentially life-threatening anaphylaxis requiring immediate care.

Treatment aims to alleviate symptoms, prevent future reactions, and address potentially life-threatening complications. Effective management of type I hypersensitivity centers on allergen avoidance, prompt recognition, and appropriate treatment. Epinephrine remains the first-line treatment for anaphylaxis, with patients advised to carry and know how to use auto-injectors. Antihistamines, corticosteroids, bronchodilators, and other adjunctive medications help manage additional symptoms, such as urticaria, pruritus, and bronchospasm. Clinicians may consider immunotherapy for long-term desensitization in select patients.

This activity for healthcare professionals is designed to enhance the learner's competence when diagnosing and managing type I hypersensitivity reactions across various clinical contexts. Participants gain a deeper understanding of the immunologic mechanisms, strengthen their ability to distinguish between mild allergic reactions and anaphylaxis, and apply evidence-based treatment protocols. This activity also underscores the importance of interprofessional collaboration in ensuring timely care, patient safety, and optimal clinical outcomes.


Target Audience

This activity has been designed to meet the educational needs of physicians, physician associates, nurses, pharmacists, and nurse practitioners.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the clinical features and immunologic mechanisms associated with type I hypersensitivity reactions, including common allergens and populations at risk.

  • Differentiate between the mild, moderate, and severe presentations of type I hypersensitivity, including urticaria, angioedema, and anaphylaxis.

  • Implement evidence-based treatment protocols for managing type 1 hypersensitivity reactions, including early intervention and supportive care measures.

  • Collaborate effectively within the interprofessional healthcare team to develop and execute comprehensive management plans for patients with type 1 hypersensitivity, ensuring coordinated care and improved patient outcomes.

Disclosures

StatPearls, LLC requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. Ineligible companies are organizations whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. Others involved in planning this educational activity have no relevant financial relationships to disclose.

Commercial Support: This activity has received NO commercial support.

Continuing Education Accreditation Information

In support of improving patient care, StatPearls, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

 

Nurses: StatPearls designates this activity for 1.50 ANCC contact hour(s). Nurses should only claim credit commensurate with the extent of their participation in the activity.

Please consult your professional licensing board for information on the applicability and acceptance of continuing education credit for this activity.

Method of Participation and Credit

  1. Register for the activity.    
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content of the enduring material.
  4. Choose the best answer to each activity test question. To receive credit and a certificate, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment survey.

If you have concerns regarding the CE/CME system, please contact support@statpearls.com.

Disclaimer

This educational activity was planned and produced in accordance with the ACCME Standards for Integrity and Independence in Accredited Continuing Education. Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls expressly disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Unapproved Uses of Drugs/Devices: In accordance with FDA requirements, the audience is advised that information presented in this continuing education activity may contain references to unlabeled or unapproved uses of drugs or devices. Please refer to the FDA-approved package insert for each drug/device for full prescribing/utilization information.

Cancellation Policy: Please see the cancellation policy. StatPearls, LLC reserves the right to cancel any course due to unforeseen circumstances.

 

 
 

Reviews

Lacey S. on 5/22/2022

Carolyn G. on 9/22/2022

Harlan H. on 3/29/2023

Mary Y. on 6/14/2023

Laura G. on 8/10/2023

ISLAM A. on 11/15/2023

Alexander H. on 2/21/2024

Nithya P. on 5/4/2024

Aneesh M. on 5/27/2024

Padmini N. on 8/4/2024

Christine G. on 8/21/2024

ishvar p. on 9/16/2024

hector L. on 9/28/2024

ROBERT G. on 10/23/2024

Timothy G. on 10/24/2024

Frank K. on 12/24/2024

Patricia K. on 1/20/2025

Sneha S. on 6/16/2025

Alice F. on 7/1/2025

Unlimited Nurse CE

Stay up to date on the latest medical knowledge with 6690 CE activities. In these online self-assessment activities, read our reference articles and test your knowledge with more than 7955 hours of CE.

Single Activity

Take this single activity

$37.50 1 activity

6 Month Unlimited Nurse CE

Access to all the Unlimited Nurse CE activities in all specialties.

$89 per half year per user

1 Year Unlimited Nurse CE

Access to all the Unlimited Nurse CE activities in all specialties.

$139 per 1 year per user